张慧君，男，副主任医师复旦大学临床医学博士2019年于美国匹兹堡大学临床医学中心（Presbyterian医院、Shadyside医院）胸心外科进修学习。200...更多简介：张慧君，男，副主任医师复旦大学临床医学博士2019年于美国匹兹堡大学临床医学中心（Presbyterian医院、Shadyside医院）胸心外科进修学习。2007-2014年在上海市肺科医院工作2017年国家自然科学青年基金项目获得者，同时参与多项国家自然基金及上海市科委课题中国肺康复协会委员上海市中西医结合学会委员。参编著作《单操作孔胸腔镜肺叶肺段切除术图谱》复旦大学出版社等著作专业方向：肺癌、食管癌，纵膈肿瘤，肺大泡，手汗症等疾病的诊断及微创外科治疗。擅长肺部磨玻璃样结节的微创治疗（精准解剖性肺段切除）、剑突下胸腔镜胸腺肿瘤/前纵膈肿瘤切除术、胸腹腔镜食管癌切除术等手术。精通晚期胸部恶性肿瘤靶向治疗及免疫治疗等综合治疗方法目前累计胸部手术量数千台目前发表学术论文数十篇，以第一作者及通讯作者发表英文论文12篇第一作者及通讯作者发表的外文学术文章：1.CT-guided hook-wire localization of malignant pulmonary nodules for video assisted thoracoscopic surgery.J Cardiothorac Surg. 2020;15(1):307. 2.Preparation, biosafety and cytotoxicity studies of a newly tumor-microenvironment-responsive biodegradable mesoporous silicon nano-system based on multi-modal and synergistic treatment. Oxid Med Cell Longev. 2020;2020:7152173.3. Down Regulation of SIRT2 Reduced ASS Induced NSCLC Apoptosis Through the Release of Autophagy Components via Exosomes. Front Cell Dev Biol. 2020; 8:601953.Giant mediastinal liposarcoma resected by 4. Giant mediastinal liposarcoma resected by Median sternotomy: a case report. Translational Cancer Research.2020.9(10) :6522-6527. 5. NCBP1 promotes the development of lung adenocarcinoma through up-regulation of CUL4B. J Cell Mol Med. 2019,23(10):6965-6977. 6. A case of chemorefractory metastatic type AB thymoma sensitive to helical tomotherapy . Ann Transl Med. 2019,7(12):274. 7. Thymosin beta 4 silencing suppresses proliferation and invasion of non-small cell lung cancer cells by repressing Notch1 activation. Acta Biochim Biophys Sin (Shanghai). 2016, 48(9):788-94.8. Co-delivery of cisplatin and paclitaxel by folic acid conjugated amphiphilic PEG-PLGA copolymer nanoparticles for the treatment of non-small lung cancer.Oncotarget, 2015, 6(39):42150-42168.9.MiR-138 inhibits tumor growth through repression of EZH2 in non-small cell lung cancer.Cellular Physiology and Biochemistry, 2013, 31(1):56-65.10. Resveratrol inhibits TGF-β1-induced epithelial-to-mesenchymal transition and suppresses lung cancer invasion and metastasis, Toxicology, 2013, 303:139-146.11. Transforming growth factor-beta1 induces epithelial-to-mesenchymal transition in human lung cancer cells via PI3K/Akt and MEK/Erk1/2 signaling pathways., Molecular Biology Reports, 2012, 39(4):3549-3556.12.Transforming growth factor-β1 promotes lung adenocarcinoma invasion and metastasis by epithelial-to-mesenchymal transition., Mol Cell Biochem, 2011, 355(1-2):309-3.收起
